Patrick Matthias is Group Leader at the Friedrich Miescher Institute for Biomedical Research in Basel since 1991. His research group for transcriptional and epigenetic networks and function of HDACs in mammals is interested in the molecular mechanisms underlying cellular plasticity. For this, they study several transcription factors and epigenetic regulators that may be relevant for B cell development. Their research also focuses on histone deacetylases (HDACs). His research group uses a broad range of methods, including the generation and analysis of transgenic or conditionally targeted mice as well as functional genomics and proteomics.
Besides many other functions, he is also President of the Forum for Genetic Research of the Swiss Academy of Sciences and Vice-President of Life Sciences Switzerland (LS2) that federates scholars from various life sciences disciplines in Switzerland.